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CD37 抗体

This 小鼠 单克隆 anti-CD37 antibody (Clone IPO-24) specifically detects CD37 in FACS, IF, WB 和 Func. The antibody is reactive with 人 samples.
产品编号 ABIN6252308
发货至: 中国
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中国
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
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Quick Overview for CD37 抗体 (ABIN6252308)

抗原

See all CD37 (TSPAN26) 抗体
CD37 (TSPAN26) (Tetraspanin 26 (TSPAN26))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This CD37 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB), Functional Studies (Func)

克隆位点

IPO-24
  • 纯化方法

    Protein G affinity chromatography

    免疫原

    Spleen cells from a patient with hairy cell leukemia were used as the immunogen for the CD37 antibody.

    亚型

    IgG2b kappa
  • 应用备注

    Functional Activity (Order SAF formulation)

    Flow Cytometry: 0.5-1 μg/million cells in 0.1ml

    Immunofluorescence: 0.5-1 μg/mL

    Optimal dilution of the CD37 antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    PBS with 0.1 mg/mL BSA and 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot and Store at -20C. Avoid freez-thaw cycles.
  • 抗原

    CD37 (TSPAN26) (Tetraspanin 26 (TSPAN26))

    别名

    CD37

    背景

    Recognizes a protein of 33-55  kDa, identified as CD37 (Workshop V, Code CD37.7). CD37 is strongly expressed on normal and neoplastic mature (sIg+) B-lymphocytes. In B-cell ontogeny, CD37 appears after the pre-B-cell stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells.1 CD37 is also present, at low densities, on resting and activated T cells, neutrophils, monocytes, and some myelomonocytic leukemia cells. It is absent from platelets, erythrocytes. CD37 is a member of a family of tetraspan transmembrane proteins, including CD9, CD53, CD63, CD81, and CD82. It associates other tetraspan transmembrane proteins and MHC class II molecules to form a large complex at the surface of B cells and play a role in signal transduction. CD37 is a valuable and stable marker for peripheral mature B-cells and corresponding malignancies like B-cell chronic lymphocytic leukemia (B-CLL), hairy cell leukemia (HCL), and all types of B-cell non-Hodgkin'' lymphoma (B-NHL).

    基因ID

    951

    UniProt

    P11049

    途径

    Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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