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Endoglin 抗体 (AA 74-251)

The 小鼠 单克隆 anti-Endoglin antibody is suitable to detect Endoglin in samples from 人. It has been validated for WB, FACS 和 IF.
产品编号 ABIN6252250
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for Endoglin 抗体 (AA 74-251) (ABIN6252250)

抗原

See all Endoglin (ENG) 抗体
Endoglin (ENG)

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This Endoglin antibody is un-conjugated

应用范围

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Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF)

克隆位点

ENG-1326
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    AA 74-251

    纯化方法

    Protein G affinity chromatography

    免疫原

    A partial recombinant protein corresponding to amino acids 74-251 of human CD105/Endoglin was used as the immunogen for the CD105 antibody.

    亚型

    IgG1
  • 应用备注

    Immunofluorescence: 1-2 μg/mL

    WB: 1-2 μg/mL

    Flow Cytometry: 0.5-1 μg/million cells in 0.1ml

    Titering of the CD105 antibody may be required for optimal performance.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    PBS with 0.1 mg/mL BSA and 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot and Store at -20C. Avoid freez-thaw cycles.
  • 抗原

    Endoglin (ENG)

    别名

    CD105

    背景

    CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. CD105 has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. It is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.
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