Aurora Kinase B 抗体 (AA 89-251)
Quick Overview for Aurora Kinase B 抗体 (AA 89-251) (ABIN6251796)
抗原
See all Aurora Kinase B (AURKB) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 89-251
-
纯化方法
- Protein G affinity
-
免疫原
- Amino acids 89-251 were used as the immunogen for this Aurora B antibody.
-
亚型
- IgG2b
-
-
-
-
应用备注
-
Western blot: 0.5-1 μg/mL
Flow Cytometry: 0.5-1 μg/10e6 cells in 0.1ml
IF: 1-2 μg/mL
Optimal dilution of the Aurora B antibody should be determined by the researcher. -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.2 mg/mL
-
缓冲液
- PBS with 0.1 mg/mL BSA and 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Aliquot and Store at -20C. Avoid freez-thaw cycles.
-
-
- Aurora Kinase B (AURKB)
-
别名
- Aurora B
-
背景
- Recognizes a protein of 39-45 kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.
-
基因ID
- 9212
-
UniProt
- Q96GD4
-
途径
- TCR Signaling, Cell Division Cycle, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades
抗原
-