DKK2 抗体
Quick Overview for DKK2 抗体 (ABIN6244156)
抗原
See all DKK2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- This antibody is purified through a protein G column, followed by dialysis against PBS.
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免疫原
- This DKK2 antibody is generated from a mouse immunized with a recombinant protein of human DKK2.
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亚型
- IgG1 kappa
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应用备注
- WB: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- DKK2 (Dickkopf 2 Homolog (DKK2))
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别名
- DKK2
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背景
- Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
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分子量
- 28447
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UniProt
- Q9UBU2
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途径
- WNT signaling
抗原
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