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MAD2L2 抗体 (C-Term)

This anti-MAD2L2 antibody is a 兔 多克隆 antibody detecting MAD2L2 in WB, IF 和 IHC (p). Suitable for 小鼠.
产品编号 ABIN6243877
发货至: 中国

Quick Overview for MAD2L2 抗体 (C-Term) (ABIN6243877)

抗原

See all MAD2L2 抗体
MAD2L2 (MAD2 Mitotic Arrest Deficient-Like 2 (MAD2L2))

适用

  • 46
  • 13
  • 12
小鼠

宿主

  • 45
  • 2

克隆类型

  • 34
  • 13
多克隆

标记

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  • 2
  • 1
  • 1
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  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
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  • 1
  • 1
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This MAD2L2 antibody is un-conjugated

应用范围

  • 35
  • 17
  • 14
  • 13
  • 12
  • 11
  • 5
  • 4
  • 4
  • 3
  • 2
  • 1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB48484
  • 抗原表位

    • 15
    • 10
    • 3
    • 1
    • 1
    • 1
    • 1
    AA 198-231, C-Term

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This MAD2L2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 198-231 amino acids from the C-terminal region of human MAD2L2.

    亚型

    Ig Fraction
  • 应用备注

    IF: 1:25. WB: 1:1000. IHC-P: 1:25

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • 抗原

    MAD2L2 (MAD2 Mitotic Arrest Deficient-Like 2 (MAD2L2))

    别名

    MAD2L2

    背景

    Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.

    分子量

    24334

    UniProt

    Q9UI95
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