EPH Receptor B4 抗体 (C-Term)
Quick Overview for EPH Receptor B4 抗体 (C-Term) (ABIN6243858)
抗原
See all EPH Receptor B4 (EPHB4) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 889-923, C-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This Mouse Ephb4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 889-923 amino acids from the C-terminal region of Mouse Ephb4.
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亚型
- Ig Fraction
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- EPH Receptor B4 (EPHB4)
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别名
- Ephb4
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背景
- Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.
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分子量
- 108848
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UniProt
- P54761
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途径
- RTK signaling
抗原
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