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CSK 抗体 (AA 164-197)

This anti-CSK antibody (ABIN6243609) is a Rabbit Polyclonal antibody detecting CSK in WB. Suitable for Human.
产品编号 ABIN6243609
发货至: 中国

Quick Overview for CSK 抗体 (AA 164-197) (ABIN6243609)

抗原

See all CSK 抗体
CSK (C-Src tyrosine Kinase (CSK))

适用

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宿主

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克隆类型

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多克隆

标记

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This CSK antibody is un-conjugated

应用范围

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Western Blotting (WB)

克隆位点

RB50499
  • 抗原表位

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    AA 164-197

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This CSK antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 164-197 amino acids from the Central region of human CSK.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • 抗原

    CSK (C-Src tyrosine Kinase (CSK))

    别名

    CSK

    背景

    Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

    分子量

    50704

    UniProt

    P41240

    途径

    TCR Signaling, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events
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