我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

PTK2B 抗体 (AA 769-802)

Name: PTK2B 抗体 (AA 769-802)
SKU: ABIN6243515
Availability: OutOfStock

This anti-PTK2B antibody is a 兔多克隆 antibody detecting PTK2B in WB. Suitable for 小鼠和大鼠.

Western blot analysis of lysates from mouse brain, mouse spleen, rat brain tissue (from left to right), using Ptk2b Antibody (ABIN6243515 and ABIN6577699). (PTK2B 抗体 (AA 769-802))

1 image

产品编号 ABIN6243515

发货至: 中国

Quick Overview for PTK2B 抗体 (AA 769-802) (ABIN6243515)

抗原

See all PTK2B 抗体

PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))

适用

小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This PTK2B antibody is un-conjugated

应用范围

Western Blotting (WB)

克隆位点

RB50242

Discover our top product PTK2B Primary Antibody

抗原表位
24

21

15

10

7

6

5

4

4

3

3

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 769-802

预测反应

H

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This Mouse Ptk2b antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 769-802 amino acids from the human region of Mouse Ptk2b.

亚型

Ig Fraction
anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (pTyr402) antibody
PTK2B 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (AA 1-1009) antibody
PTK2B 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated

anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (AA 682-871) antibody
PTK2B 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1F9 unconjugated

anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (pTyr402) antibody
PTK2B 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) antibody
PTK2B 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (AA 805-838), (C-Term) antibody
PTK2B 适用: 人 WB, IHC (p), IF 宿主: 兔 Polyclonal RB50594 unconjugated

anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (AA 812-861) antibody
PTK2B 适用: 人, 小鼠, 大鼠, 犬, 兔, Pig, 马, 猴, Cow, 豚鼠, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (AA 682-871) antibody
PTK2B 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal X1 unconjugated

anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (AA 815-997) antibody
PTK2B 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 5E2D5 unconjugated

anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (Tyr579) antibody
PTK2B 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
抗原

PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))

别名

Ptk2b

背景

Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T- cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption, this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation, this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376' (By similarity). Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC, this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN, this requires both SRC and PTK2/PYK2 (By similarity).

分子量

115794

UniProt

Q9QVP9

途径

EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Cell-Cell Junction Organization, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGF Signaling