ALK 抗体 (C-Term)
Quick Overview for ALK 抗体 (C-Term) (ABIN6243474)
抗原
See all ALK 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1466-1500, C-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This ALK antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1466-1500 amino acids from the C-terminal region of human ALK.
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亚型
- Ig Fraction
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anti-Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) (AA 636-666) antibody
ALK 适用: 人 IHC (p), WB 宿主: 兔 Polyclonal RB15425 unconjugated
anti-Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) (AA 1591-1620), (C-Term) antibodyALK 适用: 人 IHC (p) 宿主: 兔 Polyclonal RB1513-1514 unconjugated
anti-Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) (AA 14-43), (N-Term) antibodyALK 适用: 人 IHC (p) 宿主: 兔 Polyclonal RB1511-1512 unconjugated
anti-Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) (AA 636-666) antibodyALK 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) (AA 1517-1550) antibodyALK 适用: 小鼠 WB 宿主: 兔 Polyclonal RB50288 unconjugated
anti-Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) (AA 1517-1550) antibodyALK 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))
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别名
- ALK
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背景
- Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.
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分子量
- 176442
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UniProt
- Q9UM73
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途径
- RTK signaling
抗原
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