KAT5 抗体 (AA 367-398)
Our Local Distributor
北京 101111
Quick Overview for KAT5 抗体 (AA 367-398) (ABIN6243420)
抗原
See all KAT5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 367-398
-
纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
-
免疫原
- This KAT5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 367-398 amino acids from human KAT5.
-
亚型
- Ig Fraction
-
-
-
-
应用备注
- WB: 1:2000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
有效期
- 6 months
-
-
- KAT5 (K(lysine) Acetyltransferase 5 (KAT5))
-
别名
- KAT5
-
背景
- Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2.
-
分子量
- 58582
-
UniProt
- Q92993
-
途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
抗原
-