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DNMT1 抗体 (AA 881-914)

This 兔 多克隆 anti-DNMT1 antibody (Clone RB51461) specifically detects DNMT1 in WB, IF 和 IHC (p). The antibody is reactive with 人 和 小鼠 samples.
产品编号 ABIN6243160
发货至: 中国
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Quick Overview for DNMT1 抗体 (AA 881-914) (ABIN6243160)

抗原

See all DNMT1 抗体
DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

适用

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人, 小鼠

宿主

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克隆类型

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多克隆

标记

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This DNMT1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB51461
  • 抗原表位

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    AA 881-914

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This MouseDnmt1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 881-914 amino acids from the Central region of mouse Dnmt1.

    亚型

    Ig Fraction
  • 应用备注

    IF: 1:50. WB: 1:1000. WB: 1:1000. IHC-P: 1:25

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • 抗原

    DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

    别名

    Dnmt1

    背景

    Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.

    分子量

    183189

    UniProt

    P13864

    途径

    SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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