RAGE 抗体 (AA 174-208)
Quick Overview for RAGE 抗体 (AA 174-208) (ABIN6243045)
抗原
See all RAGE (AGER) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 174-208
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This AGER antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 174-208 amino acids from the Central region of human AGER.
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亚型
- Ig Fraction
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anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 180-402) antibody
AGER 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 1-237) antibodyAGER 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 1-404) antibodyAGER 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 151-250) antibodyAGER 适用: 人, 小鼠, 大鼠 WB, ELISA, IP, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 91-274) antibodyAGER 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-404) antibodyAGER 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1C1 unconjugated
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 91-120), (N-Term) antibodyAGER 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 76-104) antibodyAGER 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) antibody (Cy3)AGER 适用: 人, Cow WB, IHC, ELISA, ICC, IHC (p) 宿主: 小鼠 Monoclonal DD-A11 Cy3
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 173-418) antibodyAGER 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
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别名
- AGER
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背景
- Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
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分子量
- 42803
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UniProt
- Q15109
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途径
- Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins
抗原
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