ARID1A 抗体 (AA 1930-1964)
Quick Overview for ARID1A 抗体 (AA 1930-1964) (ABIN6243038)
抗原
See all ARID1A 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1930-1964
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This ARID1A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1930-1964 amino acids from human ARID1A.
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亚型
- Ig Fraction
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anti-AT Rich Interactive Domain 1A (SWI-Like) (ARID1A) antibody
ARID1A 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-AT Rich Interactive Domain 1A (SWI-Like) (ARID1A) (AA 655-816) antibodyARID1A 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-AT Rich Interactive Domain 1A (SWI-Like) (ARID1A) (AA 1717-1750) antibodyARID1A 适用: 人 WB 宿主: 兔 Polyclonal RB53540 unconjugated
anti-AT Rich Interactive Domain 1A (SWI-Like) (ARID1A) (Internal Region) antibodyARID1A 适用: 人, 小鼠 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- ARID1A (AT Rich Interactive Domain 1A (SWI-Like) (ARID1A))
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别名
- ARID1A
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背景
- Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Also involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
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分子量
- 242045
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UniProt
- O14497
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Tube Formation
抗原
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