JARID2 抗体 (AA 435-468)
Quick Overview for JARID2 抗体 (AA 435-468) (ABIN6242858)
抗原
See all JARID2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 435-468
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This Mouse Jarid2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 435-468 amino acids from the Central region of Mouse Jarid2.
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亚型
- Ig Fraction
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anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) (AA 1097-1246) antibody
JARID2 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 7H1B3 unconjugated
anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) (AA 1-159) antibodyJARID2 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) (AA 1130-1229) antibodyJARID2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) antibodyJARID2 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) (AA 301-400) antibodyJARID2 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) (AA 1107-1141), (C-Term) antibodyJARID2 适用: 小鼠 WB 宿主: 兔 Polyclonal RB52505 unconjugated
anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) (AA 201-250) antibodyJARID2 适用: 人, 小鼠, 豚鼠, 兔, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) (AA 215-264) antibodyJARID2 适用: 人, 小鼠, 豚鼠, Cow, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) (AA 1027-1246) antibodyJARID2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) (N-Term) antibodyJARID2 适用: 人, 大鼠, 小鼠, 豚鼠, 兔, 犬, Cow WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))
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别名
- Jarid2
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背景
- Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
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分子量
- 137445
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UniProt
- Q62315
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途径
- Chromatin Binding
抗原
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