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CDK8 抗体 (C-Term)

This anti-CDK8 antibody is a 兔 多克隆 antibody detecting CDK8 in WB. Suitable for 人.
产品编号 ABIN6242788
发货至: 中国

Quick Overview for CDK8 抗体 (C-Term) (ABIN6242788)

抗原

See all CDK8 抗体
CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

适用

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宿主

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克隆类型

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多克隆

标记

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This CDK8 antibody is un-conjugated

应用范围

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Western Blotting (WB)

克隆位点

RB51053
  • 抗原表位

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    AA 424-458, C-Term

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This Mouse Cdk8 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 424-458 amino acids from the C-terminal region of Mouse Cdk8.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • 抗原

    CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

    别名

    Cdk8

    背景

    Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation (By similarity).

    分子量

    53210

    UniProt

    Q8R3L8

    途径

    Cell Division Cycle, Regulation of Lipid Metabolism by PPARalpha
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