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Nischarin 抗体 (AA 5-38)

This anti-Nischarin antibody is a 兔 多克隆 antibody detecting Nischarin in WB. Suitable for 人 和 小鼠.
产品编号 ABIN6242733
发货至: 中国

Quick Overview for Nischarin 抗体 (AA 5-38) (ABIN6242733)

抗原

See all Nischarin (NISCH) 抗体
Nischarin (NISCH)

适用

  • 11
  • 5
  • 1
人, 小鼠

宿主

  • 11
  • 4

克隆类型

  • 11
  • 4
多克隆

标记

  • 15
This Nischarin antibody is un-conjugated

应用范围

  • 13
  • 10
  • 9
  • 7
  • 5
  • 1
Western Blotting (WB)

克隆位点

RB55910
  • 抗原表位

    • 3
    • 3
    • 1
    • 1
    • 1
    AA 5-38

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This NISCH antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 5-38 amino acids from human NISCH.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:2000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • 抗原

    Nischarin (NISCH)

    别名

    NISCH

    背景

    Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.

    分子量

    166629

    UniProt

    Q9Y2I1
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