RBM8A 抗体 (AA 79-112)
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北京 101111
Quick Overview for RBM8A 抗体 (AA 79-112) (ABIN6242599)
抗原
See all RBM8A 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 79-112
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预测反应
- X, B, Rat
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This RBM8A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 79-112amino acids from the Central region of human RBM8A.
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亚型
- Ig Fraction
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anti-RNA Binding Motif Protein 8A (RBM8A) antibody
RBM8A 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-RNA Binding Motif Protein 8A (RBM8A) (AA 1-174) antibodyRBM8A 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3E4 unconjugated
anti-RNA Binding Motif Protein 8A (RBM8A) antibodyRBM8A 适用: 人, 非洲爪蟾 WB, ELISA, IF, ICC, FACS, IP, IHC (p) 宿主: 小鼠 Monoclonal 4C4 unconjugated
anti-RNA Binding Motif Protein 8A (RBM8A) (N-Term) antibodyRBM8A 适用: 人, 大鼠, 小鼠, 斑马鱼, Cow, 犬, 马, Pig, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-RNA Binding Motif Protein 8A (RBM8A) antibodyRBM8A 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 24GB1020 unconjugated Recombinant Antibody
anti-RNA Binding Motif Protein 8A (RBM8A) (AA 1-175) antibodyRBM8A 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3E4 unconjugated
anti-RNA Binding Motif Protein 8A (RBM8A) (N-Term) antibodyRBM8A 适用: 人, 大鼠, 小鼠, 斑马鱼, Cow, 犬, 马, 非洲爪蟾, Pig, 兔, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-RNA Binding Motif Protein 8A (RBM8A) (N-Term) antibodyRBM8A 适用: 人, 大鼠, 小鼠, 斑马鱼, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-RNA Binding Motif Protein 8A (RBM8A) (AA 212-553) antibodyRBM8A 适用: E. coli WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-RNA Binding Motif Protein 8A (RBM8A) antibodyRBM8A 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- RBM8A (RNA Binding Motif Protein 8A (RBM8A))
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别名
- RBM8A
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背景
- Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP- bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. The MAGOH-RBM8A heterodimer is a component of the nonsense mediated decay (NMD) pathway. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the function is different from the established EJC assembly.
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分子量
- 19889
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UniProt
- Q9Y5S9
抗原
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