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PTEN 抗体 (C-Term)

Name: PTEN 抗体 (C-Term)
SKU: ABIN6242539
Availability: OutOfStock

This anti-PTEN antibody is a 兔多克隆 antibody detecting PTEN in WB, IF 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 1 publication.

The anti-PTEN Pab (ABIN6242539 and ABIN6579043) is used in Western blot to detect PTEN in HL-60 cell lysate. (PTEN 抗体 (C-Term))

PTEN Antibody (C-term ) ((ABIN6242539 and ABIN6579043))immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. (PTEN 抗体 (C-Term))

IHC (p)

Confocal immunofluorescent analysis of PTEN Antibody (C-term ) (ABIN6242539 and ABIN6579043) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (PTEN 抗体 (C-Term))

3 images

(1 reference)

产品编号 ABIN6242539

发货至: 中国

Quick Overview for PTEN 抗体 (C-Term) (ABIN6242539)

抗原

See all PTEN 抗体

PTEN (Phosphatase and Tensin Homolog (PTEN))

适用

人

宿主

兔

克隆类型

多克隆

标记

This PTEN antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB5083

Discover our top product PTEN Primary Antibody

抗原表位
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AA 264-295, C-Term

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This PTEN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 264-295 amino acids from the C-terminal region of human PTEN.

亚型

Ig Fraction
anti-Phosphatase and Tensin Homolog (PTEN) (AA 69-104), (N-Term) antibody
PTEN 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB05082 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 69-104) antibody
PTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 306-335) antibody
PTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 264-295) antibody
PTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 363-392) antibody
PTEN 适用: 人 WB 宿主: 兔 Polyclonal RB39439 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 371-403) antibody
PTEN 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 10-44), (N-Term) antibody
PTEN 适用: 人, 小鼠, 大鼠 WB 宿主: 小鼠 Monoclonal 1096CT4-3-3 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (pSer385) antibody
PTEN 适用: 人 DB 宿主: 兔 Polyclonal RB39440 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (pTyr315) antibody
PTEN 适用: 人 DB 宿主: 兔 Polyclonal RB30516 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (pTyr176) antibody
PTEN 适用: 人 DB 宿主: 兔 Polyclonal RB39742 unconjugated

应用备注

IF: 1:10~50. WB: 1:1000. IHC-P: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Agouni, Mody, Owen, Czopek, Zimmer, Bentires-Alj, Bence, Delibegović: "Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress." in: The Biochemical journal, Vol. 438, Issue 2, pp. 369-78, (2011) (PubMed).
抗原

PTEN (Phosphatase and Tensin Homolog (PTEN))

别名

PTEN

背景

PTEN, (phosphatase and tensin homolog deleted on chromosome 10), also known as MMAC1 (mutated in multiple advanced cancers 1), is a tumor suppressor implicated in a large number of human tumors. The PTEN phosphatase incorporates the catalytic motif (HCXXGXXRS/T) that is a signature of the protein tyrosine phosphatase family. Recombinant human PTEN is a dual phosphatase with ability to dephosphorylate both tyrosine and serine/threonine residues. PTEN functions primarily as a lipid phosphatase to regulate signal transduction pathways, with a primary target identified as phosphatidylinositol 3,4,5 trisphosphate. In addition, PTEN presents weak tyrosine phosphatase activity, which may downregulate signaling pathways involving focal adhesion kinase or Shc. PTEN negatively regulates activation of the serine/threonine kinase Akt/PKB by blocking its phosphorylation, thereby inhibiting the PI 3 kinase Akt signaling pathway, which is important for cell survival. In vivo, the majority of PTEN missense mutations detected in tumor specimens target the phosphatase domain and cause a loss in PTEN phosphatase activity. Mutations in PTEN are associated with several common cancers including prostate, brain and breast cancer, and with Cowden's disease, an autosomal dominant disorder conferring susceptibility to benign and malignant tumors. Germline mutations of PTEN are also linked Lhermitte-Duclos disease and Bannayan-Zonana syndrome. Mutations of PTEN occur in 60 to 80 % of prostate cancers. PTEN is also essential for embryonic development.

分子量

47166

NCBI登录号

NP_000305

UniProt

P60484

途径

TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling