PKN1 抗体 (AA 836-870)
Quick Overview for PKN1 抗体 (AA 836-870) (ABIN6242529)
抗原
See all PKN1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 836-870
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预测反应
- B, D
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This PKN1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 836-870 amino acids from human PKN1.
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亚型
- Ig Fraction
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anti-Protein Kinase N1 (PKN1) (AA 462-615) antibody
PKN1 适用: 人 WB, ELISA, IF, IP, RNAi 宿主: 小鼠 Monoclonal 1B10 unconjugated
anti-Protein Kinase N1 (PKN1) (AA 442-620) antibodyPKN1 适用: 人 ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 4H10B1 unconjugated
anti-Protein Kinase N1 (PKN1) (AA 1-300) antibodyPKN1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N1 (PKN1) (AA 615-874) antibodyPKN1 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N1 (PKN1) (AA 1-942) antibodyPKN1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N1 (PKN1) (Internal Region) antibodyPKN1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase N1 (PKN1) (AA 1-942) antibodyPKN1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Kinase N1 (PKN1) (Center) antibodyPKN1 适用: 人, 小鼠, Cow, 猴 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
- IF: 1:25. WB: 1:2000. IHC-P: 1:25. FC: 1:25
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- PKN1 (Protein Kinase N1 (PKN1))
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别名
- PKN1
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背景
- PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser- 159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.
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分子量
- 103932
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UniProt
- Q16512
抗原
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