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OTUB1 抗体 (AA 185-219)

This anti-OTUB1 antibody is a 兔 多克隆 antibody detecting OTUB1 in WB. Suitable for 人 和 小鼠.
产品编号 ABIN6242508
发货至: 中国

Quick Overview for OTUB1 抗体 (AA 185-219) (ABIN6242508)

抗原

See all OTUB1 抗体
OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))

适用

  • 62
  • 32
  • 19
  • 6
  • 5
  • 5
  • 5
  • 4
  • 3
  • 2
人, 小鼠

宿主

  • 73
  • 7
  • 1

克隆类型

  • 73
  • 8
多克隆

标记

  • 39
  • 13
  • 10
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This OTUB1 antibody is un-conjugated

应用范围

  • 70
  • 30
  • 21
  • 18
  • 13
  • 13
  • 12
  • 10
  • 6
  • 4
  • 3
  • 3
  • 1
Western Blotting (WB)

克隆位点

RB53068
  • 抗原表位

    • 15
    • 13
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 185-219

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This OTUB1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 185-219 amino acids from human OTUB1.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000-1:2000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • 抗原

    OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))

    别名

    OTUB1

    背景

    Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys- 48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin.

    分子量

    31284

    UniProt

    Q96FW1
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