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- 抗原 See all OTUB1 抗体
- OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))
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抗原表位
- AA 2-201
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This OTUB1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Ubiquitin thioesterase OTUB1 protein (2-201AA)
- 亚型
- IgG
- Top Product
- Discover our top product OTUB1 Primary Antibody
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anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) antibody
OTUB1 适用: 人 WB, IHC, IHC (p), FACS 宿主: 小鼠 Monoclonal 5B8 unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) antibodyOTUB1 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2H1 unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) antibodyOTUB1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5F7 unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (Internal Region) antibodyOTUB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (AA 1-220) antibodyOTUB1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) antibodyOTUB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) antibodyOTUB1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (AA 1-271) antibodyOTUB1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C12 unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (Center) antibodyOTUB1 适用: 人, 小鼠 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (AA 1-271) antibodyOTUB1 适用: 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))
- 别名
- OTUB1 (OTUB1 产品)
- 别名
- OTB1 antibody, OTU1 antibody, AI850305 antibody, fa19h07 antibody, otub1 antibody, wu:fa19h07 antibody, zgc:92839 antibody, MGC131231 antibody, fb17f04 antibody, otub1l antibody, wu:fb17f04 antibody, zgc:92685 antibody, OTU deubiquitinase, ubiquitin aldehyde binding 1 antibody, OTU domain, ubiquitin aldehyde binding 1 antibody, OTU deubiquitinase, ubiquitin aldehyde binding 1b antibody, OTU deubiquitinase, ubiquitin aldehyde binding 1 L homeolog antibody, similar to HSPC263 antibody, OTU deubiquitinase, ubiquitin aldehyde binding 1a antibody, OTUB1 antibody, Otub1 antibody, otub1b antibody, otub1.L antibody, otub1 antibody, RGD1565010 antibody, otub1a antibody
- 背景
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Background: Hydrolase that can specifically remove \\\'Lys-48\\\'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of \\\'Lys-48\\\'-linked polyubiquitin chains, but not \\\'Lys-63\\\'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to \\\'Lys-48\\\'-linked ubiquitin. Plays a key non-catalytic role in DNA repair regulation by inhibiting activity of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of \\\'Lys-63\\\'-linked histone H2A and H2AX at DNA damage sites. Inhibits RNF168 independently of ubiquitin thioesterase activity by binding and inhibiting UBE2N/UBC13, the E2 partner of RNF168, thereby limiting spreading of \\\'Lys-63\\\'-linked histone H2A and H2AX marks. Inhibition occurs by binding to free ubiquitin: free ubiquitin acts as an allosteric regulator that increases affinity for UBE2N/UBC13 and disrupts interaction with UBE2V1. The OTUB1-UBE2N/UBC13-free ubiquitin complex adopts a configuration that mimics a cleaved \\\'Lys48\\\'-linked di-ubiquitin chain.
Aliases: Deubiquitinating enzyme OTUB1 antibody, hOTU1 antibody, HSPC263 antibody, OTB1 antibody, OTU domain containing ubiquitin aldehyde binding protein 1 antibody, OTU domain, ubiquitin aldehyde binding 1 antibody, OTU domain-containing Ubal-binding protein 1 antibody, OTU domain-containing ubiquitin aldehyde-binding protein 1 antibody, OTU-domain Ubal-binding 1 antibody, OTU1 antibody, Otub1 antibody, OTUB1_HUMAN antibody, Otubain 1 antibody, Otubain-1 antibody, Ubiquitin specific processing protease OTUB1 antibody, Ubiquitin thioesterase OTUB1 antibody, ubiquitin-specific protease otubain 1 antibody, Ubiquitin-specific-processing protease OTUB1 antibody
- UniProt
- Q96FW1
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