Tec Protein Tyrosine Kinase (TEC) (AA 254-288) 抗体
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Quick Overview for Tec Protein Tyrosine Kinase (TEC) (AA 254-288) 抗体 (ABIN6242484)
抗原
See all Tec Protein Tyrosine Kinase (TEC) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 254-288
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This TEC antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 254-288 amino acids from the Central region of human TEC.
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亚型
- Ig Fraction
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anti-Tec Protein Tyrosine Kinase (TEC) (AA 1-280) antibody
TEC 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tec Protein Tyrosine Kinase (TEC) (AA 175-205) antibodyTEC 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB03266 unconjugated
anti-Tec Protein Tyrosine Kinase (TEC) (AA 612-631) antibodyTEC 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tec Protein Tyrosine Kinase (TEC) (AA 370-623) antibodyTEC 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tec Protein Tyrosine Kinase (TEC) antibodyTEC 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3A5 unconjugated
anti-Tec Protein Tyrosine Kinase (TEC) antibodyTEC 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB4520 unconjugated Recombinant Antibody
anti-Tec Protein Tyrosine Kinase (TEC) (AA 612-631), (C-Term) antibodyTEC 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tec Protein Tyrosine Kinase (TEC) (AA 503-552) antibodyTEC 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, Bat, 猴, 小鸡, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Tec Protein Tyrosine Kinase (TEC) (AA 369-622) antibodyTEC 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tec Protein Tyrosine Kinase (TEC) (Middle Region) antibodyTEC 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- Tec Protein Tyrosine Kinase (TEC)
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别名
- TEC
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背景
- Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation.
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分子量
- 73581
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UniProt
- P42680
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途径
- Fc-epsilon Receptor Signaling Pathway
抗原
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