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ABL1 抗体 (pTyr251)

Name: ABL1 抗体 (pTyr251)
SKU: ABIN6241067
Availability: OutOfStock

This anti-ABL1 antibody is a 兔多克隆 antibody detecting ABL1 in WB, IF, IHC (p) 和 DB. Suitable for 人. This Primary Antibody has been cited in 1 publication.

Western blot analysis of anti-ABL Pab (ABIN6241067 and ABIN6578924) in Hela cell line lysate (35 μg/lane). (ABL1 抗体 (pTyr251))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (ABL1 抗体 (pTyr251))

IHC (p)

Confocal immunofluorescent analysis of Phospho-ABL1- Antibody (ABIN6241067 and ABIN6578924) with MCF-7 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (ABL1 抗体 (pTyr251))

Dot blot analysis of anti-Phospho-ABL1- Antibody (ABIN6241067 and ABIN6578924) on nitrocellulose membrane. (ABL1 抗体 (pTyr251))

4 images

(1 reference)

产品编号 ABIN6241067

发货至: 中国

Quick Overview for ABL1 抗体 (pTyr251) (ABIN6241067)

抗原

See all ABL1 抗体

ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

适用

人

宿主

兔

克隆类型

多克隆

标记

This ABL1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Dot Blot (DB)

克隆位点

RB7351

Discover our top product ABL1 Primary Antibody

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pTyr251

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This ABL1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y251 of human ABL1.

亚型

Ig Fraction
anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (AA 490-590) antibody
ABL1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (pTyr245) antibody
ABL1 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (pTyr412) antibody
ABL1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (pTyr393), (pTyr412) antibody
ABL1 适用: 人, 小鼠, 猴 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (pTyr412) antibody
ABL1 适用: 人, 小鼠, 猴 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (AA 741-769) antibody
ABL1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (pTyr393), (pTyr439) antibody
ABL1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (pTyr204) antibody
ABL1 适用: 人, 小鼠 IF 宿主: 兔 Polyclonal unconjugated

anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (pTyr245) antibody
ABL1 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated

anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (pTyr412) antibody
ABL1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100. DB: 1:500

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Asmussen, Lasater, Tajon, Oses-Prieto, Jun, Taylor, Burlingame, Craik, Shah: "MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction." in: Cancer discovery, Vol. 4, Issue 2, pp. 200-15, (2014) (PubMed).
抗原

ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

别名

ABL1

背景

ABL1 is a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9,22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.

分子量

122873

NCBI登录号

NP_005148, NP_009297

UniProt

P00519

途径

Apoptosis, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism