RPS6KA3 抗体 (pThr573)
Quick Overview for RPS6KA3 抗体 (pThr573) (ABIN6240990)
抗原
See all RPS6KA3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pThr573
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免疫原
- synthetic peptide
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anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) antibody
RPS6KA3 适用: 人 WB, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 4E10 unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (AA 1-740) antibodyRPS6KA3 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (AA 2-95) antibodyRPS6KA3 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2G10 unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (Center) antibodyRPS6KA3 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (pTyr529) antibodyRPS6KA3 适用: 人, 小鼠 ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (pThr573) antibodyRPS6KA3 适用: 人, 小鼠 ELISA, IF (p), IF (cc), IHC (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (pSer227) antibodyRPS6KA3 适用: 人, 大鼠 ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (AA 214-431) antibodyRPS6KA3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) (AA 2-95) antibodyRPS6KA3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) antibodyRPS6KA3 适用: 人, 小鼠, 猴 WB, IP 宿主: 小鼠 Monoclonal 6B9-D6-F8 unconjugated
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应用备注
- WB: 1:1000. IHC: 1:50~100
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限制
- 仅限研究用
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状态
- Liquid
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储存条件
- 4 °C,-20 °C
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- RPS6KA3 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3))
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别名
- p90 RSK
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背景
- Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin- derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro- apoptotic proteins BAD and DAPK1 and suppressing their pro- apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression.
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UniProt
- Q15418
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途径
- MAPK Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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