CTNND1 抗体 (pTyr96)
Quick Overview for CTNND1 抗体 (pTyr96) (ABIN6178401)
抗原
See all CTNND1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pTyr96
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原理
- Mouse Monoclonal anti-Catenin, delta-1 (25a), Purified, BSA-free
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产品特性
- The membrane associated protein pp120 Src substrate (p120 Catenin, p120cas) was identified as a tyrosine kinase substrate that is phosphorylated in Src transformed cells or in response to growth factor stimulation. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate beta-catenin and gamma-catenin proteins. Its characteristic Arm domain that is composed of 42-amino acid motif repeats evidences this similarity. In the cell, p120 Catenin is localized to the E-Cadherin/catenins cell adhesion complex. Like beta- and gamma-catenin, p120 Catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain and may similarly interact with other Cadherins. It exists as four isoforms that range in size from 90-115 kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered pp120 expression contributes to malignancy due to loss of functional cell adhesions. Multiple tyrosine residues (Y96, Y112, Y228, Y280, Y257, Y291, Y296, and Y302) in p120 Catenin are phosphorylated by Src and these phosphorylations may facilitate interaction with PTP1C/SHP-1 in response to EGF stimulation. Thus, p120 Catenin is an Arm domain protein that interacts with both cell adhesion molecules, such as cadherins and cell signaling molecules, such as PTP1C. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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纯化方法
- Purified
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免疫原
- Mouse p120 Catenin (pY96)
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亚型
- IgG1 kappa
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anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (AA 573-832) antibody
CTNND1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) antibodyCTNND1 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (AA 841-890) antibodyCTNND1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (Tyr228) antibodyCTNND1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (AA 482-605) antibodyCTNND1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) antibodyCTNND1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (pTyr228) antibodyCTNND1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (pTyr228) antibodyCTNND1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (AA 1-610) antibodyCTNND1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (N-Term) antibodyCTNND1 适用: 人, 小鼠, 大鼠, 豚鼠, 犬, 兔, 马, Pig, Cow WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Immunofluorescence 1-2 μg/mL
- Optimal dilution for a specific application should be determined by user
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说明
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Carcinoma
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS (no BSA, no azide)
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储存液
- Azide free
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- CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))
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别名
- Catenin, delta-1
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背景
- Cadherin-associated Src substrate (CAS), Catenin (cadherin associated protein) delta 1, Catenin delta-1, CTNND1, p120 catenin, P120 CTN, p120(cas), p120(ctn), P120CAS, P120CTN
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分子量
- 120 kDa
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基因ID
- 1500
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途径
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling
抗原
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