VEGFB 抗体 (AA 21-188)
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Quick Overview for VEGFB 抗体 (AA 21-188) (ABIN616026)
抗原
See all VEGFB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 21-188
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特异性
- This antibody detects VEGF-B.
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交叉反应 （详细）
- Species reactivity (tested):Human
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纯化方法
- Protein-A purified
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免疫原
- Highly pure (>95%) recombinant human VEGF-B167 (Ala21-Arg188) derived from E. coli
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亚型
- IgG
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anti-Vascular Endothelial Growth Factor B (VEGFB) (AA 100-200) antibody
VEGFB 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Vascular Endothelial Growth Factor B (VEGFB) (AA 22-207) antibodyVEGFB 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Vascular Endothelial Growth Factor B (VEGFB) (AA 22-207) antibodyVEGFB 适用: 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Vascular Endothelial Growth Factor B (VEGFB) (AA 22-137) antibodyVEGFB 适用: 犬 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Vascular Endothelial Growth Factor B (VEGFB) (AA 25-207) antibodyVEGFB 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Vascular Endothelial Growth Factor B (VEGFB) (AA 22-207) antibodyVEGFB 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Vascular Endothelial Growth Factor B (VEGFB) (Internal Region) antibodyVEGFB 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Vascular Endothelial Growth Factor B (VEGFB) (AA 101-207) antibodyVEGFB 适用: 人 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Vascular Endothelial Growth Factor B (VEGFB) antibodyVEGFB 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Vascular Endothelial Growth Factor B (VEGFB) (Internal Region) antibodyVEGFB 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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溶解方式
- Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
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缓冲液
- PBS, pH 7.2
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- The lyophilized antibody is stable at room temperature for up to 1 month. Following reconstitution antibody can be stored at 2-8 °C for up to two weeks or (in aliquots) at -20 °C for longer.
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- VEGFB (Vascular Endothelial Growth Factor B (VEGFB))
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别名
- VEGF-B
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背景
- Vascular endothelial growth factor B (VEGF-B), also known as vascular endothelial growth factor-related factor (VRF), is a member of the VEGF family of growth factors that share structural and functional similarity (1, 2). Five mammalian members, including VEGF-A, B, C, D and PlGF, have been identified. VEGF family members are disulfide-linked dimeric proteins that are important regulators of physiological and pathological vasculogenesis, angiogenesis and lymphangiogenesis. VEGF-B is expressed in most tissues, especially in heart, skeletal muscle and pancreas. In many tissues, VEGF-B is coexpressed and can heterodimerize with VEGF (3). By alternative splicing, two isoforms of mature VEGF-B containing 167 or 186 amino acid (aa) residues exist (3, 4). The two VEGF-B isoforms have identical amino-terminal cysteine knot VEGF homology domains but the carboxyl end of VEGF-B167 differs from that of VEGF-B186 by the presence of a highly basic cysteine-rich heparin binding domain. Whereas VEGF-B186 is a secreted diffusible protein, VEGF-B167 is sequestered into the cell matrix after secretion. Both VEGF-B isoforms bind VEGF receptor 1 (VEGFR-1), but not VEGFR-2 or VEGFR-3 (5). On endothelial cells, ligation of VEGFR-1 by VEGF-B has been shown to regulate the expression and activity of urokinase type plasminogen activator and plasminogen activator inhibitor 1. VEGF-B167 and a proteolytically processed form of VEGF-B186 (VEGF-B127) also bind neuropilin1 (NP1), a type I transmembrane receptor for semaphorins/collapsins, ligands involved in neuron guidance (6). Besides VEGF-B, NP1 has been shown to bind PlGF-2, VEGF165 and VEGFR-1 (6, 7). The many interactions of NP1 with VEGF ligands and receptor suggest that NP1 may function as a regulator of angiogenesis (7).Synonyms: VEGF-related factor, VEGFB, VRF, Vascular endothelial growth factor B
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基因ID
- 7423
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NCBI登录号
- NP_003368
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UniProt
- P49765
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途径
- RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
抗原
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