KIT Ligand 抗体 (AA 26-189)
Quick Overview for KIT Ligand 抗体 (AA 26-189) (ABIN616022)
抗原
See all KIT Ligand (KITLG) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 26-189
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特异性
- This antibody detects KITLG / SCF.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse
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纯化方法
- Protein-A purified
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免疫原
- Highly pure (>95%) recombinant mouse SCF (Lys26-Ala189) derived from E. coli
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亚型
- IgG
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anti-KIT Ligand (KITLG) (AA 151-250) antibody
KITLG 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-KIT Ligand (KITLG) antibodyKITLG 适用: 人 WB, ELISA, Neut 宿主: 兔 Polyclonal unconjugated
anti-KIT Ligand (KITLG) (AA 26-190) antibodyKITLG 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-KIT Ligand (KITLG) (AA 244-273) antibodyKITLG 适用: 人 WB, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-KIT Ligand (KITLG) (Middle Region) antibodyKITLG 适用: 人, 小鼠, 大鼠, Pig, 犬, Cow, 山羊, 马, 兔, 绵羊, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-KIT Ligand (KITLG) (AA 180-229) antibodyKITLG 适用: 人, 小鼠, 大鼠, Pig, 犬, Cow, 山羊, 马, 兔, 绵羊, 小鸡, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-KIT Ligand (KITLG) (Middle Region) antibodyKITLG 适用: 人, 小鼠, 大鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-KIT Ligand (KITLG) antibodyKITLG 适用: 人, 小鼠, 大鼠 WB, IHC (p), ELISA (Capture) 宿主: 兔 Polyclonal unconjugated
anti-KIT Ligand (KITLG) (AA 201-234), (C-Term) antibodyKITLG 适用: 人 WB 宿主: 兔 Polyclonal RB50736 unconjugated
anti-KIT Ligand (KITLG) antibody (Biotin)KITLG 适用: 小鼠 WB, ELISA, Neut 宿主: 兔 Polyclonal Biotin
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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溶解方式
- Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
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缓冲液
- PBS, pH 7.2
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- The lyophilized antibody is stable at room temperature for up to 1 month. Following reconstitution antibody can be stored at 2-8 °C for up to two weeks or (in aliquots) at -20 °C for longer.
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- KIT Ligand (KITLG)
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别名
- KITLG / SCF
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背景
- Stem cell factor (SCF), also known as ckit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28-40 kDa type I transmembrane glycoprotein (1). It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors (1-7). SCF is a primary growth and activation factor for mast cells and eosinophils (8). Mature mouse SCF consists of a 189 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment, and a 36 aa cytoplasmic tail (9). The ECD shows both N-linked and O-linked glycosylation (10). Proteolytic cleavage at two alternate sites in the extracellular juxtamembrane region releases a 25 kDa soluble molecule which is comparable to the only form produced by Steel-dickie mutant mice (11, 12). An alternately spliced isoform of mouse SCF lacks 28 aa that encompasses the primary proteolytic recognition site (13). Within the ECD of the short isoform (corresponding to this recombinant protein), mouse SCF shares 93 % aa sequence identity with rat SCF and 72 % 75 % with canine, feline, and human SCF. Rat SCF is active on mouse and human cells, but human SCF is only weakly active on mouse cells (14). Noncovalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF R/ckit to trigger receptor dimerization and signaling (15). SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels (16).Synonyms: KITL, Kit ligand, MGF, Mast cell growth factor, Stem cell factor, c-Kit ligand
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基因ID
- 17311
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NCBI登录号
- NP_038626
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UniProt
- P20826
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
抗原
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