PHLDA3 抗体 (C-Term)
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Quick Overview for PHLDA3 抗体 (C-Term) (ABIN615985)
抗原
See all PHLDA3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- C-RARQSLGTGT LVS
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特异性
- Recognizes PHLDA3 / TIH1
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
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免疫原
- synthetic peptide corresponding to the C Terminus of the protein sequence of Huuman PHLDA3 (NP_036528.1). Genename: PHLDA3
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anti-Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) antibody
PHLDA3 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) (AA 1-31), (N-Term) antibodyPHLDA3 适用: 人 WB 宿主: 小鼠 Monoclonal 4B6 unconjugated
anti-Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) (Internal Region) antibodyPHLDA3 适用: 人 ELISA, IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) (AA 43-95) antibodyPHLDA3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) (C-Term) antibodyVerified PHLDA3 适用: 人 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
anti-Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) (C-Term) antibodyPHLDA3 适用: 人, 小鼠, 大鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) (Internal Region) antibodyPHLDA3 适用: 人, 小鼠, 大鼠 ELISA, IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) (AA 38-87) antibodyPHLDA3 适用: 人, 小鼠, 大鼠, 豚鼠, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) (N-Term) antibodyPHLDA3 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- PHLDA3 (Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3))
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别名
- PHLDA3
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背景
- P53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor. The PH domain binds phosphoinositides with a broad specificity. It competes with the PH domain of AKT1 and directly interferes with AKT1 binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-triphosphate (PIP3), preventing AKT1 association to membrane lipids and subsequent activation of AKT1 signaling.Synonyms: Pleckstrin homology-like domain family A member 3, TDAG51/Ipl homologue 1, TIH1
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基因ID
- 23612
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NCBI登录号
- NP_036528
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UniProt
- Q9Y5J5
抗原
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