POLG 抗体 (AA 829-1201)
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Quick Overview for POLG 抗体 (AA 829-1201) (ABIN615477)
抗原
See all POLG 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 829-1201
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特异性
- This antibody detects POLG1.
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Immunoaffinity Chromatography
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免疫原
- Recombinant protein fragment containing a sequence corresponding to a region within amino acids 829 and 1201 of DNA polymerase gamma.
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anti-Polymerase (DNA Directed), gamma (POLG) (C-Term) antibody
POLG 适用: 人 WB, ICC, IHC (p), IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), gamma (POLG) (AA 1101-1239) antibodyPOLG 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), gamma (POLG) antibodyKD Validated POLG 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB1085 unconjugated Recombinant Antibody
anti-Polymerase (DNA Directed), gamma (POLG) (AA 1041-1239) antibodyPOLG 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), gamma (POLG) antibodyPOLG 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Polymerase (DNA Directed), gamma (POLG) (AA 446-590) antibodyPOLG 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), gamma (POLG) (AA 242-291) antibodyPOLG 适用: 人, 小鼠, 大鼠, Cow, Bat, Hamster, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), gamma (POLG) (N-Term) antibodyPOLG 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), gamma (POLG) (AA 1120-1148), (C-Term) antibodyPOLG 适用: 人, 小鼠 WB, IHC (p), IF, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.7 mg/mL
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缓冲液
- PBS, pH 7, 1 % BSA, 20 % Glycerol and 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody (in aliquots) at -20 °C. Dilute only prior to immediate use.
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- POLG (Polymerase (DNA Directed), gamma (POLG))
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别名
- POLG1
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背景
- As the only DNA polymerase (pol) present in mitochondria, DNA polymerase gamma (POLG) is necessarily implicated in base excision repair processes to correct oxidative damage to the mitochondrial genome. Therefore, the ability of the catalytic subunit of human POLG has been tested to participate in uracil provoked base excision repair reconstituted in vitro with purified components. Subsequent to actions of uracil DNA glycosylase and apurinic / apyrimidinic endonuclease, human POLG is able to fill a single nucleotide gap in the presence of a 5' terminal deoxyribose phosphate (dRP) flap. The catalytic subunit of human pol gamma catalyzes release of the dRP residue from incised apurinic / apyrimidinic sites to produce a substrate for DNA ligase. Faulty replication of the human mitochondrial genome is thought to be the cause of many diseases. The low selectivity of the mitochondrial DNA polymerase is implicated as the cause of many side effects observed in the treatment of viral infections such as HIV.Synonyms: DNA polymerase subunit gamma-1, MDP1, Mitochondrial DNA polymerase catalytic subunit, POLG, POLGA, PolG-alpha
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基因ID
- 5428
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NCBI登录号
- NP_001119603
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UniProt
- P54098
抗原
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