OPTN 抗体 (AA 575-591)
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Quick Overview for OPTN 抗体 (AA 575-591) (ABIN615041)
抗原
See all OPTN 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 575-591
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特异性
- This antibody reacts to Optineurin (OPTN).
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纯化方法
- Immunoaffinity Chromatography
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免疫原
- OPTN antibody was raised against synthetic peptide corresponding to aa 575-591 (G575EVLPDIDTLQIHVMDC591) of human, mouse and rat optineurin (FIP-2 (14.7K interacting protein-2), NRP (nemo-related protein)). Genename: OPTN
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- TBS, pH 7.4 containing 0.5 mg/mL BSA, 0.02 % sodium azide, 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- OPTN (Optineurin (OPTN))
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别名
- Optineurin / HIP7
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背景
- Optineurin (OTPN), a coiled-coil containing protein, may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins.Synonyms: E3-14.7K-interacting protein, FIP-2, FIP2, GLC1E, HYPL, Huntingtin yeast partner L, Huntingtin-interacting protein 7, Huntingtin-interacting protein L, NEMO-related protein, NRP, Optic neuropathy-inducing protein, Transcription factor IIIA-interacting protein
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基因ID
- 10133
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NCBI登录号
- NP_001008212
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UniProt
- Q96CV9
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途径
- M Phase
抗原
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