Vitamin D Receptor 抗体 (AA 1-428)
Quick Overview for Vitamin D Receptor 抗体 (AA 1-428) (ABIN614675)
抗原
See all Vitamin D Receptor (VDR) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-428
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特异性
- This antibody reacts to Vitamin D Receptor (VDR).
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纯化方法
- Protein A Chromatography
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免疫原
- Recombinant protein, VDR (AAH60832, 1 a.a. ~ 428 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Genename: VDR
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亚型
- IgG2a
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anti-Vitamin D Receptor (VDR) (AA 65-180) antibody
VDR 适用: 人, 小鼠, 大鼠 WB, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Vitamin D Receptor (VDR) (AA 1-427) antibodyVDR 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Vitamin D Receptor (VDR) (AA 1-300) antibodyVDR 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Vitamin D Receptor (VDR) (AA 377-402), (C-Term) antibodyVDR 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Vitamin D Receptor (VDR) (N-Term) antibodyVDR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Vitamin D Receptor (VDR) (pSer208) antibodyVDR 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Vitamin D Receptor (VDR) (AA 266-422) antibodyVDR 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Vitamin D Receptor (VDR) antibodyVDR 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 3C7 unconjugated Recombinant Antibody
anti-Vitamin D Receptor (VDR) (AA 1-428) antibodyVDR 适用: 人 ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2F4 unconjugated
anti-Vitamin D Receptor (VDR) (AA 1-427) antibodyVDR 适用: 人 ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2F4 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0,5 mg/mL
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缓冲液
- PBS, pH 7.2
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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- Vitamin D Receptor (VDR)
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别名
- Vitamin D3 Receptor / NR1I1
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物质类
- Chemical
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背景
- The vitamin D receptor, a NR1 Thyroid Hormone-Like Receptor, is activated by calcitriol, the active hormonal form of vitamin D. The activated receptor binds DNA at a specific vitamin D-responsive element and promotes transcription of vitamin D target genes such as osteocalcin, the most abundant noncollagenous protein in bone. The vitamin D receptor affects growth, bone formation, and female reproduction. For example, this receptor modulates the growth and differentiation of keratinocytes and mediates the beneficial effects of vitamin D on psoriatic skin. It also inhibits hormone secretion by and proliferation of parathyroid cells. The vitamin D receptor functions either as a homodimer or as a heterodimer of vitamin D and retinoid acid X receptor subunits. Inactivation of the receptor leads to hypocalcemia and Rickets-alopecia syndrome. Recently, the vitamin D receptor has been shown to function as a receptor for the secondary bile acid lithocholic acid (LCA), which is hepatotoxic and a potential enteric carcinogen. Activation of VDR by LCA or vitamin D induced expression in vivo of CYP3A, a cytochrome P450 enzyme that detoxifies LCA in the liver and intestine. An alternatively spliced vitamin D receptor that has an altered ligand-binding domain has been isolated from rats.Synonyms: 1, 25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, VDR
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基因ID
- 7421
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NCBI登录号
- NP_000367
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UniProt
- P11473
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途径
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
抗原
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