PIAS4 抗体 (AA 60-260)
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- 抗原 See all PIAS4 抗体
- PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))
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抗原表位
- AA 60-260
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PIAS4 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- ELYETRYAKK NSEPAPQPHR PLDPLTMHST YDRAGAVPRT PLAGPNIDYP VLYGKYLNGL GRLPAKTLKP EVRLVKLPFF NMLDELLKPT ELVPQNNEKL QESPCIFALT PRQVELIRNS RELQPGVKAV QVVLRICYSD TSCPQEDQYP PNIAVKVNHS YCSVPGYYPS NKPGVEPKRP CRPINLTHLM YLSSATNRIT V
- 交叉反应
- 人, 小鼠
- 产品特性
- Polyclonal Antibodies
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 60-260 of human PIAS4 (NP_056981.2).
- 亚型
- IgG
- Top Product
- Discover our top product PIAS4 Primary Antibody
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- 应用备注
- WB,1:500 - 1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))
- 别名
- PIAS4 (PIAS4 产品)
- 背景
- Functions as an E3-type small ubiquitin-like modifier (SUMO ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.,PIAS4,PIAS-gamma,PIASY,Piasg,ZMIZ6,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,NF-kB Signaling Pathway,PIAS4
- 分子量
- 56 kDa
- 基因ID
- 51588
- UniProt
- Q8N2W9
- 途径
- JAK/STAT Signaling, Interferon-gamma Pathway, Positive Regulation of Response to DNA Damage Stimulus
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