PATZ1 抗体 (AA 250-350)
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北京 101111
Quick Overview for PATZ1 抗体 (AA 250-350) (ABIN6145252)
抗原
See all PATZ1 (ZNF278) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 250-350
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序列
- PFPSVASSAP PLTGKRGRGR PRKANLLDSM FGSPGGLREA GILPCGLCGK VFTDANRLRQ HEAQHGVTSL QLGYIDLPPP RLGENGLPIS EDPDGPRKRS R
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 250-350 of human PATZ1 (NP_114440.1).
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亚型
- IgG
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应用备注
- WB,1:1000 - 1:4000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- PATZ1 (ZNF278) (Zinc Finger Protein 278 (ZNF278))
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别名
- PATZ1
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背景
- The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1,22)(p36.1,q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.,PATZ1,MAZR,PATZ,RIAZ,ZBTB19,ZNF278,ZSG,dJ400N23,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,PATZ1
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分子量
- 57 kDa/69 kDa/74 kDa
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基因ID
- 23598
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UniProt
- Q9HBE1
抗原
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