DNMT3B 抗体 (AA 1-200)
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北京 101111
Quick Overview for DNMT3B 抗体 (AA 1-200) (ABIN6139751)
抗原
See all DNMT3B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-200
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序列
- MKGDTRHLNG EEDAGGREDS ILVNGACSDQ SSDSPPILEA IRTPEIRGRR SSSRLSKREV SSLLSYTQDL TGDGDGEDGD GSDTPVMPKL FRETRTRSES PAVRTRNNNS VSSRERHRPS PRSTRGRQGR NHVDESPVEF PATRSLRRRA TASAGTPWPS PPSSYLTIDL TDDTEDTHGT PQSSSTPYAR LAQDSQQGGM
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human DNMT3B (NP_008823.1).
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亚型
- IgG
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应用备注
- WB,1:200 - 1:1000,IHC,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))
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别名
- DNMT3B
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背景
- CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.,DNMT3B,ICF,ICF1,M.HsaIIIB,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,DNA methylation,DNMT3B
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分子量
- 77-95 kDa
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基因ID
- 1789
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UniProt
- Q9UBC3
抗原
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