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DNMT1 抗体 (AA 1-270)

Name: DNMT1 抗体 (AA 1-270)
Brand: antibodies-online
SKU: ABIN6139745
Availability: OutOfStock

This anti-DNMT1 antibody is a 兔多克隆 antibody detecting DNMT1 in WB, IP 和 IF. Suitable for 人. This Primary Antibody has been cited in 3+ publications.

Western blot analysis of extracts of various cell lines, using DNMT1 antibody. (DNMT1 抗体 (AA 1-270))

Critical residues for the interaction between DNMT1 and USP7. (DNMT1 抗体 (AA 1-270))

IF (cc)

USP7-DNMT1 interaction is required for USP7-mediated stabilization of DNMT1. (DNMT1 抗体 (AA 1-270))

Acetylation of KGDNMT1impairs DNMT1-USP7 interaction and promotes the degradation of DNMT1. (DNMT1 抗体 (AA 1-270))

IF (cc)

9 images

(3 references)

产品编号 ABIN6139745

发货至: 中国

Quick Overview for DNMT1 抗体 (AA 1-270) (ABIN6139745)

抗原

See all DNMT1 抗体

DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

适用

人

宿主

兔

克隆类型

多克隆

标记

This DNMT1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

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AA 1-270

序列

MPARTAPARV PTLAVPAISL PDDVRRRLKD LERDSLTEKE CVKEKLNLLH EFLQTEIKNQ LCDLETKLRK EELSEEGYLA KVKSLLNKDL SLENGAHAYN REVNGRLENG NQARSEARRV GMADANSPPK PLSKPRTPRR SKSDGEAKPE PSPSPRITRK STRQTTITSH FAKGPAKRKP QEESERAKSD ESIKEEDKDQ DEKRRRVTSR ERVARPLPAE EPERAKSGTR TEKEEERDEK EEKRLRSQTK EPTPKQKLKE EPDREARAGV

交叉反应

人

产品特性

Polyclonal Antibodies

纯化方法

Affinity purification

免疫原

Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human DNMT1 (NP_001370.1).

亚型

IgG
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) antibody
DNMT1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) antibody
KO Validated DNMT1 适用: 人 WB, IHC, IP, IF, ChIP 宿主: 兔 Monoclonal unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1448-1594) antibody
DNMT1 适用: 人, 猴 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 7C11A2 unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 21-120) antibody
DNMT1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1-270) antibody
DNMT1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1317-1616) antibody
DNMT1 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 2D10G8 unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 881-914) antibody
DNMT1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB51461 unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 637-650) antibody
DNMT1 适用: 人 WB, IHC, IP, ChIP 宿主: 小鼠 Monoclonal 60B1220-1 unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1317-1616) antibody
DNMT1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D5G2 unconjugated

anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 22-126) antibody
DNMT1 适用: 人 WB, ELISA, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB,1:500 - 1:2000,IF,1:50 - 1:200,IP,1:50 - 1:100

说明

HIGH QUALITY

限制

仅限研究用
状态

Liquid

缓冲液

PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20°C. Avoid freeze / thaw cycles.
Xie, Zhang, Wang, Zhao, Zhang, Yao, Hur, Yeh, Pang, Zheng, Fan, Kong, Wang, Chiu, Zhou: "Matrix stiffness determines the phenotype of vascular smooth muscle cell in vitro and in vivo: Role of DNA methyltransferase 1." in: Biomaterials, Vol. 155, pp. 203-216, (2018) (PubMed).

Wang, Li, Zhu, Lin, Luo, Zhao, Zhang, Li, Gao, Liang, Liu, Tsun, Yuan, Wu, Li: "DNMT1 cooperates with MBD4 to inhibit the expression of Glucocorticoid-induced TNFR-related protein in human T cells." in: FEBS letters, Vol. 591, Issue 13, pp. 1929-1939, (2017) (PubMed).

Xi, Gao, Yang, Ye, Zhang, Wu, Jiang, Zhang: "Anticancer drugs induce hypomethylation of the acetylcholinesterase promoter via a phosphorylated-p38-DNMT1-AChE pathway in apoptotic hepatocellular carcinoma cells." in: The international journal of biochemistry & cell biology, Vol. 68, pp. 21-32, (2016) (PubMed).
抗原

DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

别名

DNMT1

背景

This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.,ADCADN,AIM,CXXC9,DNMT,HSN1E,MCMT,m.HsaI,DNMT1,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,DNA methylation,DNMT1

分子量

144 kDa/183 kDa/184 kDa

基因ID

1786

UniProt

P26358

途径

SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection