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BIM 抗体 (AA 30-130)

This anti-BIM antibody is a 兔 多克隆 antibody detecting BIM in IHC. Suitable for 人.
产品编号 ABIN6137558
发货至: 中国

Quick Overview for BIM 抗体 (AA 30-130) (ABIN6137558)

抗原

See all BIM (BCL2L11) 抗体
BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

适用

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宿主

  • 109
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克隆类型

  • 94
  • 27
多克隆

标记

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This BIM antibody is un-conjugated

应用范围

  • 83
  • 50
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Immunohistochemistry (IHC)
  • 抗原表位

    • 15
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    AA 30-130

    序列

    PGAPTSLQTE PQGNPEGNHG GEGDSCPHGS PQGPLAPPAS PGPFATRSPL FIFMRRSSLL SRSSSGYFSF DTDRSPAPMS CDKSTQTPSP PCQAFNHYLS A

    交叉反应

    产品特性

    Polyclonal Antibodies

    纯化方法

    Affinity purification

    免疫原

    Recombinant fusion protein containing a sequence corresponding to amino acids 30-130 of human Bim (NP_619527.1).

    亚型

    IgG
  • 应用备注

    IHC,1:50 - 1:100

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

    别名

    Bim

    背景

    The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.,BAM,BIM,BOD,Bim,BCL2L11,Cancer,Invasion and Metastasis,Signal Transduction,Kinase,PI3K-Akt Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Bcl 2 family,Mitochondrial Control of Apoptosis,Inhibition of Apoptosis,Endocrine & Metabolism,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Bim

    分子量

    4-22 kDa

    基因ID

    10018

    UniProt

    O43521

    途径

    PI3K-Akt Signaling, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity
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