NEURL 抗体 (Tyr1248)
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北京 101111
Quick Overview for NEURL 抗体 (Tyr1248) (ABIN5962106)
抗原
See all NEURL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Tyr1248
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特异性
- Verb b2 erythroblastic leukemia viral oncogene homolog 2,neuro/glioblastoma derived oncogene homolog,C erb B2/neu protein,CD340,CD340 antigen,Cerb B2/neu protein,CerbB2,Erb b2 receptor tyrosine kinase 2,ERBB2,ERBB2,HER 2,HER 2/NEU,HER2,Herstatin,Human epidermal growth factor receptor 2,Metastatic lymph node gene 19 protein,MLN 19,MLN19,NEU,NEU proto oncogene,Neuro/glioblastoma derived oncogene homolog,Neuroblastoma/glioblastoma derived oncogene homolog,NGL,p185erbB2,Proto-oncogene c-ErbB-2,Proto-oncogene Neu,Receptor tyrosine-protein kinase erbB-2,TKR1,Tyrosine kinase type cell surface receptor HER2,Tyrosine kinase-type cell surface receptor HER2,V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog),V erb b2 avian erythroblastic leukemia viral oncogene homolog 2,V erb b2 avian erythroblastic leukemia viral oncoprotein 2,V erb b2 erythroblastic leukemia viral oncogene homolog 2,neuro/glioblastoma derived oncogene homolog (avian),V erb b2 erythroblastic leukemia viral oncogene homolog 2,neuro/glioblastoma derived oncogene homolog,Verb b2 erythroblastic leukemia viral oncogene homolog 2,neuro/glioblastoma derived oncogene homolog (avian)
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纯化方法
- Affinity purification
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免疫原
- Synthesized peptide derived from human Neu around the non-phosphorylation site of Tyr1248.
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亚型
- IgG
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anti-Neuralized Homolog (Drosophila) (NEURL) (Internal Region) antibody
NEURL 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neuralized Homolog (Drosophila) (NEURL) (pTyr1248) antibodyNEURL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuralized Homolog (Drosophila) (NEURL) (Internal Region) antibodyNEURL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuralized Homolog (Drosophila) (NEURL) (Ser357) antibodyNEURL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuralized Homolog (Drosophila) (NEURL) (Center) antibodyNEURL 适用: 人 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Neuralized Homolog (Drosophila) (NEURL) (AA 158-186) antibodyNEURL 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB21920 unconjugated
anti-Neuralized Homolog (Drosophila) (NEURL) (AA 107-156) antibodyNEURL 适用: 人, 小鼠, 大鼠, 猴, Cow, 犬, 豚鼠, 马, 兔, Bat, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Neuralized Homolog (Drosophila) (NEURL) (pTyr1112) antibodyNEURL 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neuralized Homolog (Drosophila) (NEURL) (pTyr1221), (pTyr1222) antibodyNEURL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Neuralized Homolog (Drosophila) (NEURL) (pTyr877) antibodyNEURL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- NEURL (Neuralized Homolog (Drosophila) (NEURL))
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别名
- Neu
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背景
- Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A, the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
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分子量
- 138kDa
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基因ID
- 2064
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UniProt
- P04626
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途径
- Notch Signaling, EGFR Signaling Pathway
抗原
-
