EPO 抗体
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北京 101111
Quick Overview for EPO 抗体 (ABIN5708355)
抗原
See all EPO 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Antigen affinity purified
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免疫原
- A recombinant mouse protein corresponding to amino acids D34-R192 was used as the immunogen for the Erythropoietin antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the Erythropoietin antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,ELISA: 0.1-0.5 μg/mL (mouse protein tested)
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the Erythropoietin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- EPO (Erythropoietin (EPO))
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别名
- Erythropoietin
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物质类
- Hormone
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背景
- The EPO gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies.
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UniProt
- P01588
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途径
- JAK/STAT Signaling, Hormone Activity, Negative Regulation of intrinsic apoptotic Signaling, Negative Regulation of Transporter Activity
抗原
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