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NKX2-1 抗体

This anti-NKX2-1 antibody is a 兔 单克隆 antibody detecting NKX2-1 in IHC (p). Suitable for 人.
产品编号 ABIN5708021
发货至: 中国

Quick Overview for NKX2-1 抗体 (ABIN5708021)

抗原

See all NKX2-1 抗体
NKX2-1 (NK2 Homeobox 1 (NKX2-1))

适用

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宿主

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克隆类型

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单克隆

标记

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This NKX2-1 antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

HBNK2-2R
  • 纯化方法

    Purified

    纯度

    Protein A affinity chromatography

    免疫原

    Recombinant protein was used as the immunogen for the recombinant NKX2.1 antibody.

    亚型

    IgG kappa
  • 应用备注

    The stated application concentrations are suggested starting points. Titration of the recombinant NKX2.1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

    1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

    限制

    仅限研究用
  • 缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    4 °C,-20 °C

    储存方法

    Store the recombinant NKX2.1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    NKX2-1 (NK2 Homeobox 1 (NKX2-1))

    别名

    NKX2.1 / TTF-1

    背景

    NKX2.1/TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-NKX2.1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. NKX2.1 reactivity is also seen in thyroid malignancies.

    途径

    Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Cellular Glucan Metabolic Process, Feeding Behaviour
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