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beta Catenin 抗体

This anti-beta Catenin antibody is a 兔 单克隆 antibody detecting beta Catenin in IHC (p). Suitable for 人.
产品编号 ABIN5707937
发货至: 中国

Quick Overview for beta Catenin 抗体 (ABIN5707937)

抗原

See all beta Catenin (CATNB) 抗体
beta Catenin (CATNB) (Catenin, beta (CATNB))

适用

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宿主

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克隆类型

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单克隆

标记

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This beta Catenin antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

CTNNB1-2030R
  • 纯化方法

    Purified

    纯度

    Protein A affinity chromatography

    免疫原

    Human protein was used as the immunogen for the recombinant b-Catenin antibody.

    亚型

    IgG kappa
  • 应用备注

    Titration of the recombinant b-Catenin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

    1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. IHC (FFPE): 1-2 μg/mL,Prediluted IHC only format : incubate for 30 min at RT (1)

    限制

    仅限研究用
  • 缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    4 °C,-20 °C

    储存方法

    Store the recombinant b-Catenin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    beta Catenin (CATNB) (Catenin, beta (CATNB))

    别名

    Beta Catenin

    背景

    The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. [RefSeq]

    途径

    Peptide Hormone Metabolism
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