Recombinant KRT15 抗体
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北京 101111
Quick Overview for Recombinant KRT15 抗体 (ABIN5707765)
抗原
See all KRT15 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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原理
- Recombinant Cytokeratin 15 Antibody / Rabbit Monoclonal (azide and preservative free)
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纯化方法
- Protein A affinity chromatography
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免疫原
- Recombinant human protein was used as the immunogen for the recombinant Cytokeratin 15 antibody.
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亚型
- IgG, kappa
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应用备注
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Optimal dilution of the recombinant Cytokeratin 15 antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the recombinant Cytokeratin 15 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- KRT15 (Keratin 15 (KRT15))
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别名
- Cytokeratin 15
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背景
- Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.
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UniProt
- P19012
抗原
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