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KRT15 抗体

This 兔 单克隆 anti-KRT15 antibody (Clone KRT15-2103R) specifically detects KRT15 in IHC (p). The antibody is reactive with 人 samples.
产品编号 ABIN5707765
发货至: 中国
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Quick Overview for KRT15 抗体 (ABIN5707765)

抗原

See all KRT15 抗体
KRT15 (Keratin 15 (KRT15))

适用

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宿主

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克隆类型

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单克隆

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This KRT15 antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

KRT15-2103R
  • 纯化方法

    Purified

    纯度

    Protein A affinity chromatography

    免疫原

    Recombinant human protein was used as the immunogen for the recombinant Cytokeratin 15 antibody.

    亚型

    IgG kappa
  • 应用备注

    Optimal dilution of the recombinant Cytokeratin 15 antibody should be determined by the researcher.

    1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format : incubate for 30 min at RT (1)

    限制

    仅限研究用
  • 缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    4 °C,-20 °C

    储存方法

    Store the recombinant Cytokeratin 15 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    KRT15 (Keratin 15 (KRT15))

    别名

    KRT15 / Cytokeratin 15

    背景

    Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.
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