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NGFR 抗体

This anti-NGFR antibody is a 兔 单克隆 antibody detecting NGFR in IHC (p). Suitable for 人, 大鼠 和 Non-Human Primate.
产品编号 ABIN5707551
发货至: 中国

Quick Overview for NGFR 抗体 (ABIN5707551)

抗原

See all NGFR 抗体
NGFR (Nerve Growth Factor Receptor (NGFR))

适用

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人, 大鼠, Non-Human Primate

宿主

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克隆类型

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单克隆

标记

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This NGFR antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

NGFR-1997R
  • 交叉反应 (详细)

    Not suitable for mouse

    纯化方法

    Purified

    纯度

    Protein A affinity chromatography

    免疫原

    Recombinant human protein was used as the immunogen for the recombinant p75NTR antibody.

    亚型

    IgG kappa
  • 应用备注

    Optimal dilution of the recombinant p75NTR antibody should be determined by the researcher.

    1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

    限制

    仅限研究用
  • 缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    4 °C,-20 °C

    储存方法

    Store the recombinant p75NTR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    NGFR (Nerve Growth Factor Receptor (NGFR))

    别名

    NGF Receptor / p75NTR / CD271

    背景

    This antibody is specific for a glycoprotein of 75  kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or p75 Neurotrophin Receptor (p75NTR). NGFR is expressed in various neural crest cells and their tumors such as melanocytes, melanomas, neuroblastomas, pheochromocytomas and neurofibromas. Reportedly, anti-NGFR/p75NTR is a reliable marker for desmoplastic and neurotropic melanomas. It is expressed in mature non-neural cells such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells, and myoepithelial cells. Anti-NGFR/p75NTR stains the myoepithelial cells of breast ducts and intra-lobular fibroblasts of breast ducts.

    途径

    NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
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