CLIP 抗体 (AA 25-39)
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北京 101111
Quick Overview for CLIP 抗体 (AA 25-39) (ABIN5707527)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 25-39
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纯化方法
- Purified
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纯度
- Protein A affinity chromatography
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免疫原
- Amino acids 25-39 (NGAEDESAEAFPLEF) of Adrenocorticotropic hormone (CLIP sequence) were used as the immunogen for this ACTH antibody.
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亚型
- IgG kappa
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anti-Corticotropin-Like Intermediate Peptide (CLIP) (AA 156-176) antibody
CLIP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Corticotropin-Like Intermediate Peptide (CLIP) (AA 156-176) antibodyCLIP 适用: 人 WB 宿主: 小鼠 Monoclonal ABM52H4 unconjugated
anti-Corticotropin-Like Intermediate Peptide (CLIP) (AA 25-39) antibodyCLIP 适用: 人 FACS, IF, IHC (p), ELISA 宿主: 小鼠 Monoclonal ADCT1-1 unconjugated
anti-Corticotropin-Like Intermediate Peptide (CLIP) (AA 25-39) antibodyCLIP 适用: 人 FACS, IF, IHC (p), ELISA 宿主: 小鼠 Monoclonal ADCT1-1 unconjugated
anti-Corticotropin-Like Intermediate Peptide (CLIP) antibodyCLIP 适用: 人 FACS, IF, WB 宿主: 小鼠 Monoclonal CLIP-1133 unconjugated
anti-Corticotropin-Like Intermediate Peptide (CLIP) (AA 25-39) antibodyCLIP 适用: 人, 大鼠, 小鼠 IHC (p) 宿主: 兔 Monoclonal CLIP-2040R unconjugated
anti-Corticotropin-Like Intermediate Peptide (CLIP) antibodyCLIP 适用: 人 FACS, IF, WB 宿主: 小鼠 Monoclonal CLIP-1133 unconjugated
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应用备注
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The optimal dilution of the recombinant ACTH antibody for each application should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format : incubate for 30 min at RT (1) -
限制
- 仅限研究用
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the recombinant ACTH antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- CLIP (Corticotropin-Like Intermediate Peptide (CLIP))
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别名
- ACTH / CLIP
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背景
- ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This mAb is specific to CLIP (aa 17-39 of ACTH) and does not react with Synacthen (aa 1-24 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.
抗原
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