SNRPN 抗体
Quick Overview for SNRPN 抗体 (ABIN5704719)
抗原
See all SNRPN 抗体适用
宿主
克隆类型
标记
应用范围
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免疫原
- survival of motor neuron 2, centromeric
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亚型
- IgG
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anti-Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) (AA 46-95) antibody
SNRPN 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) (AA 1-240) antibodySNRPN 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) (AA 1-100) antibodySNRPN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) (Internal Region) antibodySNRPN 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB : 1:500-1:5000 IP : 1:500-1:5000 IHC : 1:50-1:200 IF : 1:10-1:100
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说明
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K-562 cells were subjected to SDS PAGE followed by western blot with FNab08031(SMN2 antibody) at dilution of 1:2000
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限制
- 仅限研究用
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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有效期
- 12 months
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- SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))
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别名
- SMN
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背景
- Synonyms:C BCD541, Component of gems 1, FLJ76644, Gemin 1, SMN, SMN1, SMN1, SMN, SMN2, SMNC, SMNT, Survival motor neuron protein Background:This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. While mutations in the telomeric copy are associated with spinal muscular atrophy, mutations in this gene, the centromeric copy, do not lead to disease. This gene may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The full length protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Four transcript variants encoding distinct isoforms have been described.
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分子量
- 38 kDa
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UniProt
- Q16637
抗原
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