SKP2 抗体
Quick Overview for SKP2 抗体 (ABIN5701277)
抗原
See all SKP2 抗体适用
宿主
克隆类型
标记
应用范围
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免疫原
- S-phase kinase-associated protein 2 (p45)
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab07898( SKP2 Antibody) at dilution of 1:600
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限制
- 仅限研究用
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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有效期
- 12 months
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- SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))
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别名
- SKP2
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背景
- Synonyms:FBXL1 Background:This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class, in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms.
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基因ID
- 6502
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UniProt
- Q13309
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途径
- Mitotic G1-G1/S Phases
抗原
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