DAB2 抗体
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Quick Overview for DAB2 抗体 (ABIN5700687)
抗原
See all DAB2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- DAB2 antibody
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免疫原
- disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
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亚型
- IgG
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anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) (AA 1-770) antibody
DAB2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) (AA 31-130) antibodyDAB2 适用: 人, 大鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) (AA 743-770), (C-Term) antibodyDAB2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB23472 unconjugated
anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) (pSer24) antibodyDAB2 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) (C-Term) antibodyDAB2 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) (AA 743-770) antibodyDAB2 适用: 人 WB, IHC, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) antibodyKD Validated DAB2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB225 unconjugated Recombinant Antibody
anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) (AA 673-770) antibodyDAB2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C8 unconjugated
anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) (AA 1-770) antibodyDAB2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D6 unconjugated
anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) (AA 624-650), (C-Term) antibodyDAB2 适用: 小鼠 WB 宿主: 兔 Polyclonal RB40861 unconjugated
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应用备注
- WB : 1:500-1:5000 IP : 1:1000-1:10000 IF : 1:20-1:200
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说明
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HeLa cells were subjected to SDS PAGE followed by western blot with FNab02228(DAB2 antibody) at dilution of 1:1000
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限制
- 仅限研究用
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- DAB2 (Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))
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别名
- DAB2
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背景
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Synonyms: Disabled homolog 2|Adaptor molecule disabled-2|Differentially expressed in ovarian carcinoma 2 (DOC-2)|Differentially-expressed protein 2|DAB2|DOC2
Background: Adapter protein that functions as clathrin-associated sorting protein(CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate(PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1, this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1(PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor(AR) signaling mediated by SRC activation, seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm(VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor.
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分子量
- 96 kDa
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基因ID
- 1601
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UniProt
- P98082
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process
抗原
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