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MMP2 抗体 (AA 424-660)

This anti-MMP2 antibody is a 兔 多克隆 antibody detecting MMP2 in WB, IHC, ELISA 和 IP. Suitable for 人, 大鼠, 小鼠 和 斑马鱼.
产品编号 ABIN5699311
发货至: 中国

Quick Overview for MMP2 抗体 (AA 424-660) (ABIN5699311)

抗原

See all MMP2 抗体
MMP2 (Matrix Metalloproteinase 2 (MMP2))

适用

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人, 大鼠, 小鼠, 斑马鱼

宿主

  • 132
  • 50
  • 1

克隆类型

  • 127
  • 56
多克隆

标记

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  • 14
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This MMP2 antibody is un-conjugated

应用范围

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  • 18
  • 4
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Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)
  • 抗原表位

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    • 4
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    • 2
    • 2
    • 2
    • 2
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    • 2
    • 1
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    • 1
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    AA 424-660

    原理

    MMP2 antibody

    免疫原

    Immunogen sequence: 424-660aa

    Immunogen: matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

    亚型

    IgG
  • 应用备注

    WB : 1:200-1:2000 IP : 1:200-1:1000 IHC : 1:100-1:400 IF : 1:50-1:500

    说明

    MCF7 cells were subjected to SDS PAGE followed by western blot with FNab05238(MMP2 antibody) at dilution of 1:500

    限制

    仅限研究用
  • 缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze / thaw cycles.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months

    有效期

    12 months
  • 抗原

    MMP2 (Matrix Metalloproteinase 2 (MMP2))

    别名

    MMP2

    背景

    Synonyms: 72 kDa type IV collagenase|72 kDa gelatinase|Gelatinase A|Matrix metalloproteinase-2 (MMP-2)|TBE-1|PEX|MMP2|CLG4A

    Background: This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

    分子量

    72 kDa, 60 kDa

    基因ID

    4313

    UniProt

    P08253

    途径

    Activation of Innate immune Response
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