CDK4 抗体
Quick Overview for CDK4 抗体 (ABIN5699229)
抗原
See all CDK4 抗体适用
宿主
克隆类型
标记
应用范围
- 
    
- 
                                            
免疫原
 - cyclin-dependent kinase 4
 - 
                                            
亚型
 - IgG
 
 - 
                                            
 - 
    
 - 
    
- 
                                            
应用备注
 - Optimal working dilution should be determined by the investigator.
 - 
                                            
说明
 - 
                        
HeLa cells were subjected to SDS PAGE followed by western blot with FNab01557(CDK4 antibody) at dilution of 1:1000
 - 
                                            
限制
 - 仅限研究用
 
 - 
                                            
 - 
    
- 
                                            
缓冲液
 - PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
 - 
                                            
储存液
 - Sodium azide
 - 
                                            
注意事项
 - This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
 - 
                                            
注意事项
 - Avoid repeated freeze / thaw cycles.
 - 
                                            
储存条件
 - -20 °C
 - 
                                            
有效期
 - 12 months
 
 - 
                                            
 - 
    
- CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
 - 
                                            
别名
 - CDK4
 - 
                                            
背景
 - Synonyms:CDK4, Cell division protein kinase 4, CMM3, cyclin dependent kinase 4, PSK J3 Background:The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
 - 
                                            
分子量
 - 34 kDa
 - 
                                            
基因ID
 - 1019
 - 
                                            
UniProt
 - P11802
 - 
                                            
途径
 - Cell Division Cycle, Mitotic G1-G1/S Phases, Regulation of Cell Size
 
抗原
 -