Interleukin 17a 抗体 (AA 1-155)
Quick Overview for Interleukin 17a 抗体 (AA 1-155) (ABIN5698147)
抗原
See all Interleukin 17a (IL17A) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-155
-
原理
- IL17A antibody
-
免疫原
-
Immunogen sequence: 1-155aa
Immunogen: interleukin 17A
-
亚型
- IgG1
-
-
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze / thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months
-
有效期
- 12 months
-
-
- Interleukin 17a (IL17A) (Interleukin 17A (IL17A))
-
别名
- IL17A
-
背景
-
Synonyms: Interleukin-17A (IL-17, IL-17A)|Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8)|IL17A|CTLA8|IL17
Background: IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2(PTGS2/COX-2), as well as enhance the production of nitric oxide(NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.
-
分子量
- 32-35 kDa
抗原
-